NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Systemic lupus erythematosus (SLE) is an autoimmune connective-tissue disorder with a
wide range of clinical manifestations that predominantly affect women. Many aspects of its …

Stat6 is known to drive macrophage M2 polarization. However, how macrophage
polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is …

Chronic infectious diseases have a substantial impact on the human B cell compartment
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …

Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

The ubiquitination-dependent processing of NF-κB2 (also known as p100) is a critical step in
the activation of the noncanonical NF-κB pathway. We investigated the molecular …

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in
inflammatory response following myocardial ischemia/reperfusion injury. Peli1, an E3 …

Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Immune intervention of B cell activation to blockade the production of autoantibodies
provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy …

Ubiquitination is an essential mechanism in the control of antiviral immunity upon virus
infection. Here, we identify a series of ubiquitination-modulating enzymes that are …