Actin bundles dynamics and architecture

S Rajan, DS Kudryashov, E Reisler - Biomolecules, 2023 - mdpi.com
Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

Regulation of actin bundle mechanics and structure by intracellular environmental factors

N Castaneda, J Park, EH Kang - Frontiers in physics, 2021 - frontiersin.org
The mechanical and structural properties of actin cytoskeleton drive various cellular
processes, including structural support of the plasma membrane and cellular motility. Actin …

Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure

F Lehne, T Pokrant, S Parbin, G Salinas… - Nature …, 2022 - nature.com
Abstract Changes in cell morphology require the dynamic remodeling of the actin
cytoskeleton. Calcium fluxes have been suggested as an important signal to rapidly relay …

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

A Sponga, JL Arolas, TC Schwarz, CM Jeffries… - Science …, 2021 - science.org
In sarcomeres, α-actinin cross-links actin filaments and anchors them to the Z-disk. FATZ
(filamin-, α-actinin-, and telethonin-binding protein of the Z-disk) proteins interact with α …

Getting cells into shape by calcium-dependent actin cross-linking proteins

F Lehne, S Bogdan - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
The actin cytoskeleton represents a highly dynamic filament system providing cell structure
and mechanical forces to drive a variety of cellular processes. The dynamics of the actin …

Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification

Y Zhang, J Du, X Liu, F Shang, Y Deng, J Ye… - Nature …, 2024 - nature.com
Abstract α-Actinins play crucial roles in cytoskeletal mechanobiology by acting as force-
bearing structural modules that orchestrate and sustain the cytoskeletal framework, serving …

The Plasma Membrane Ca2+ Pump PMCA4b Regulates Melanoma Cell Migration through Remodeling of the Actin Cytoskeleton

R Naffa, R Padányi, A Ignácz, Z Hegyi, B Jezsó, S Tóth… - Cancers, 2021 - mdpi.com
Simple Summary Earlier we demonstrated that the plasma membrane Ca2+ pump PMCA4b
inhibits migration and metastatic activity of BRAF mutant melanoma cells, however, the exact …

[HTML][HTML] From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission

H Katsuta, M Sokabe, H Hirata - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
The contractile apparatus, stress fiber (SF), is connected to the cell adhesion machinery,
focal adhesion (FA), at the termini of SF. The SF-FA complex is essential for various …

Identification of a Novel Interaction between Theileria Prohibitin (TaPHB-1) and Bovine RuvB-Like AAA ATPase 1

PB Araveti, PP Kar, A Kuriakose, A Sanju… - Microbiology …, 2023 - Am Soc Microbiol
Theileriosis is a tick-borne disease caused by Theileria annulata, an intracellular parasite
that belongs to the phylum Apicomplexa. The infective forms of the parasite to cattle are …

Unraveling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica through proteomic analysis

AI Salgado‐Martínez, RG Avila‐Bonilla… - FEBS Open …, 2021 - Wiley Online Library
We recently reported that silencing of the polyadenylation factor EhCFIm25 in Entamoeba
histolytica, the protozoan which causes human amoebiasis, affects trophozoite proliferation …