Cancer nanomedicine for combination cancer immunotherapy
Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …
Next‐generation vaccines: nanoparticle‐mediated DNA and mRNA delivery
Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …
Nanoengineered immune niches for reprogramming the immunosuppressive tumor microenvironment and enhancing cancer immunotherapy
H Phuengkham, L Ren, IW Shin, YT Lim - Advanced Materials, 2019 - Wiley Online Library
Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …
received extensive attention and become mainstream strategies for treating cancer. Despite …
[HTML][HTML] Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …
[HTML][HTML] Doxorubicin induced heart failure: Phenotype and molecular mechanisms
MA Mitry, JG Edwards - IJC heart & vasculature, 2016 - Elsevier
Long term survival of childhood cancers is now more than 70%. Anthracyclines, including
doxorubicin, are some of the most efficacious anticancer drugs available. However, its use …
doxorubicin, are some of the most efficacious anticancer drugs available. However, its use …
Macroscale biomaterials strategies for local immunomodulation
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …
manipulation of innate and adaptive immune responses is of great promise for a wide array …
Nanomaterials for cancer immunotherapy
Cancer immunotherapy is quickly growing to be the fourth most important cancer therapy,
after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising …
after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising …
Biomaterials for vaccine-based cancer immunotherapy
R Zhang, MM Billingsley, MJ Mitchell - Journal of Controlled Release, 2018 - Elsevier
The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …
against tumors has been explored since the early discovery of tumor-specific antigens by …
Nanoparticle drug delivery systems designed to improve cancer vaccines and immunotherapy
Recent studies have demonstrated great therapeutic potential of educating and unleashing
our own immune system for cancer treatment. However, there are still major challenges in …
our own immune system for cancer treatment. However, there are still major challenges in …
[HTML][HTML] Advances in the polymeric delivery of nucleic acid vaccines
Nucleic acid vaccines, especially messenger RNA (mRNA) vaccines, display unique
benefits in the current COVID-19 pandemic. The application of polymeric materials as …
benefits in the current COVID-19 pandemic. The application of polymeric materials as …