Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

Metal–peptide complexes as promising antibiotics to fight emerging drug resistance: New perspectives in tuberculosis

C Di Natale, I De Benedictis, A De Benedictis… - Antibiotics, 2020 - mdpi.com
In metal-peptide interactions, cations form stable complexes through bonds with
coordinating groups as side chains of amino acids. These compounds, among other things …

Binuclear Cu (II), Ni (II) and Zn (II) complexes of hydrazone Schiff bases: Synthesis, spectroscopy, DFT calculations, and SOD mimetic activity

A Zengin, K Serbest, M Emirik, M Özil… - Journal of Molecular …, 2023 - Elsevier
Two new salicylaldimine-based N-heterocyclic hydrazone ligands, N'-[(2-hydroxyphenyl)
methylene]-2-(2-phenyl-1H-benzimidazol-1-yl) acetohydrazone (H 2 L 1) and 2-[2-(3 …

Copper (II)/diiminic complexes based on 2-hydroxybenzophenones: DNA-and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells

JHV Rodrigues, AB de Carvalho, VR Silva, LS Santos… - Polyhedron, 2023 - Elsevier
Here, we report four new heteroleptic Cu (II) complexes with the formula [Cu
(bipy)(2H4MeBz)] NO 3 (1),[Cu (phen)(2H4MeBz)] NO 3 (2),[Cu (bipy)(2H4OcBz)] NO 3 (3) …

Synthesis of new Cu (II)-benzohydrazide nanometer complexes, spectral, modeling, CT-DNA binding with potential anti-inflammatory and anti-allergic theoretical …

HA Katouah, JH Al-Fahemi, MG Elghalban… - Materials Science and …, 2019 - Elsevier
New nanometer Cu (II)-benzohydrazide complexes were synthesized and characterized.
Mono negative tetra-dentate mode is the general feature proposed for all coordinating …

Binucleating hydrazonic ligands and their μ-hydroxodicopper (II) complexes as promising structural motifs for enhanced antitumor activity

JP Rada, BSM Bastos, L Anselmino… - Inorganic …, 2019 - ACS Publications
Very few inorganic antineoplastic drugs have entered the clinic in the last decades, mainly
because of toxicity issues. Because copper is an essential trace element of ubiquitous …

Phototoxicity of strained Ru (ii) complexes: is it the metal complex or the dissociating ligand?

DF Azar, H Audi, S Farhat, M El-Sibai… - Dalton …, 2017 - pubs.rsc.org
A photochemically dissociating ligand in Ru (bpy) 2 (dmphen) Cl2 [bpy= 2, 2′-bipyridine;
dmphen= 2, 9-dimethyl-1, 10-phenanthroline] was found to be more cytotoxic on the ML-2 …

A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells

PHA Machado, DA Paixão, RC Lino, TR de Souza… - Scientific Reports, 2021 - nature.com
The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an
essential micronutrient and is important to tumor biology, CuII complexes emerged as an …

DNA binding, cleavage, apoptosis and cytotoxicity studies of three heteroleptic nickel complexes bearing β-diketones

LM Sousa, WA Souza, DA Paixao, RB Fazzi… - Inorganica Chimica …, 2020 - Elsevier
In this work, three nickel (II) complexes, namely,[Ni (η 2-NO 3)(bta)(phen)](I),[Ni (η 2-NO
3)(btc)(phen)](II), and [Ni (η 2-NO 3)(btf)(phen)](III)(bta= 4, 4, 4-trifluoro-1-phenyl-1, 3 …

Dual anticancer and antibacterial activities of bismuth compounds based on asymmetric [NN'O] ligands

IM Marzano, D Tomco, RJ Staples… - Journal of Inorganic …, 2021 - Elsevier
Two new bismuth (III) complexes,[BiL 1 Cl 2](1) and [BiL 2 Cl 2](2), in which L 1 is (2-hydroxy-
4-6-di-tert-butylbenzyl-2-pyridylmethyl) amine and L 2 is 2, 4-diiodo-6-((pyridine-2 …