Atherosclerosis is a chronic inflammatory disease associated with cardiovascular
dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke …

Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

The importance of fibrosis in organ pathology and dysfunction appears to be increasingly
relevant to a variety of distinct diseases. In particular, a number of different cardiac …

Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that
regulate cell-matrix composition by using zinc for their proteolytic activities. They are …

Age-related progression of cardiovascular disease is by far the largest health problem in the
US and involves vascular damage, progressive vascular fibrosis and the accumulation of …

RA is characterized by a systemic inflammatory state, in which immune cells and soluble
mediators play a crucial role. These inflammatory processes resemble those in other chronic …

The transforming growth factor type-β (TGF-β) superfamily of ligands, receptors, binding
proteins and ligand traps together plays a key role in the maintenance of normal blood …

Matrix metalloproteinases (MMPs) are extracellular matrix–modifying enzymes that are
important in many physiologic and pathologic vascular processes. Dysregulation of MMP …

Coxibs, such as rofecoxib, celecoxib, and valdecoxib, selectively inhibit cyclooxygenase
(COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non …

Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines.
Macrophages play a crucial role at all stages of this disease, including regulation of foam …