Is post-traumatic stress disorder associated with premature senescence? A review of the literature

JB Lohr, BW Palmer, CA Eidt, S Aailaboyina… - The American Journal of …, 2015 - Elsevier
Objective Post-traumatic stress disorder (PTSD) has major public health significance.
Evidence that PTSD may be associated with premature senescence (early or accelerated …

Metabolism, metabolomics, and inflammation in posttraumatic stress disorder

SH Mellon, A Gautam, R Hammamieh, M Jett… - Biological …, 2018 - Elsevier
Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations,
although among the characteristics are significantly increased rates of serious somatic …

Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis

J Cait, A Cait, RW Scott, CB Winder, GJ Mason - BMC biology, 2022 - Springer
Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

[HTML][HTML] Formation of memory assemblies through the DNA-sensing TLR9 pathway

V Jovasevic, EM Wood, A Cicvaric, H Zhang, Z Petrovic… - Nature, 2024 - nature.com
As hippocampal neurons respond to diverse types of information, a subset assembles into
microcircuits representing a memory. Those neurons typically undergo energy-intensive …

Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders

E Doney, A Cadoret, L Dion‐Albert… - European Journal of …, 2022 - Wiley Online Library
Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Innate immunity and neuroinflammation

A Shastri, DM Bonifati, U Kishore - Mediators of inflammation, 2013 - Wiley Online Library
Inflammation of central nervous system (CNS) is usually associated with trauma and
infection. Neuroinflammation occurs in close relation to trauma, infection, and …

Neuroinflammation in post-traumatic stress disorder

DH Lee, JY Lee, DY Hong, EC Lee, SW Park, MR Lee… - Biomedicines, 2022 - mdpi.com
Post-traumatic stress disorder (PTSD) is a well-known mental illness, which is caused by
various stressors, including memories of past physical assaults and psychological pressure …

Checks and balances on cholinergic signaling in brain and body function

H Soreq - Trends in neurosciences, 2015 - cell.com
A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors,
transporters, and synthesizing and degrading enzymes and regulators of their expression as …

Regional gray matter oligodendrocyte-and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans

KLP Long, LL Chao, Y Kazama, A An, KY Hu… - Translational …, 2021 - nature.com
Individual reactions to traumatic stress vary dramatically, yet the biological basis of this
variation remains poorly understood. Recent studies demonstrate the surprising plasticity of …

The link between autonomic nervous system and rheumatoid arthritis: from bench to bedside

F Ingegnoli, M Buoli, F Antonucci, LA Coletto… - Frontiers in …, 2020 - frontiersin.org
Neuronal stimulation is an emerging field of research focused on the management and
treatment of various diseases through the reestablishment of physiological homeostasis …