Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Chronological age is a crucial risk factor for diseases and disabilities among older adults.
However, individuals of the same chronological age often exhibit divergent biological aging …

Young blood plasma is known to confer beneficial effects on various organs in mice and
rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat …

Background During aging, the human methylome undergoes both differential and variable
shifts, accompanied by increased entropy. The distinction between variably methylated …

Estimators of biological age hold promise for use in preventive medicine, for early detection
of chronic conditions, and for monitoring the effectiveness of interventions aimed at …

Chronological age prediction from DNA methylation sheds light on human aging, health,
and lifespan. Current clocks are mostly based on linear models and rely upon hundreds of …

Motivation Aging is intricately linked to diseases and mortality. It is reflected in molecular
changes across various tissues which can be leveraged for the development of biomarkers …

Health problems associated with aging are a major public health concern for the future.
Aging is a complex process with wide intervariability among individuals. Therefore, there is a …

DNA methylation is a critical epigenetic modification that regulates gene expression and
plays a significant role in development and disease processes. Here, we present the …

Centenarians are of particular importance to aging research as they represent the living
architype of exceptional longevity and as such studying their attributes is expected to …