Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3–
20% of the population. Risk of olfactory dysfunction increases with old age and may also …

Background The literature regarding clinical olfaction, olfactory loss, and olfactory
dysfunction has expanded rapidly over the past two decades, with an exponential rise in the …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Primary ciliary dyskinesia (PCD) is a rare genetic ciliopathy in which mucociliary clearance
is disturbed by the abnormal motion of cilia or there is a severe reduction in the generation …

Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin,
the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of …

Olfactory inputs help coordinate food appreciation and selection, but their role in systemic
physiology and energy balance is poorly understood. Here we demonstrate that mice upon …

Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused …

Bardet-Biedl syndrome (BBS) is a defining ciliopathy, notable for extensive allelic and
genetic heterogeneity, almost all of which has been identified through sequencing. Recent …

Cilia dysfunction underlies a class of human diseases with variable penetrance in different
organ systems. Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogenesis …

Appropriate axonal growth and connectivity are essential for functional wiring of the brain.
Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations …