Cognitive dysfunction and diabetes mellitus

CT Kodl, ER Seaquist - Endocrine reviews, 2008 - academic.oup.com
The deleterious effects of diabetes mellitus on the retinal, renal, cardiovascular, and
peripheral nervous systems are widely acknowledged. Less attention has been given to the …

Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders

H Cai, W Cong, S Ji, S Rothman… - Current Alzheimer …, 2012 - ingentaconnect.com
Alzheimer's disease and other related neurodegenerative diseases are highly debilitating
disorders that affect millions of people worldwide. Efforts towards developing effective …

Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus

RA Whitmer, AJ Karter, K Yaffe, CP Quesenberry… - Jama, 2009 - jamanetwork.com
Context Although acute hypoglycemia may be associated with cognitive impairment in
children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a …

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy

LJ Launer, ME Miller, JD Williamson, RM Lazar… - The Lancet …, 2011 - thelancet.com
Background People with type 2 diabetes are at risk of cognitive impairment and brain
atrophy. We aimed to compare the effects on cognitive function and brain volume of …

Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies

A Luo, Z Xie, Y Wang, X Wang, S Li, J Yan… - Neuroscience & …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

Y Chornenkyy, WX Wang, A Wei, PT Nelson - Brain Pathology, 2019 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …

'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

LM Pérez, H Pareja‐Galeano… - The Journal of …, 2016 - Wiley Online Library
The increasing ageing of our societies is accompanied by a pandemic of obesity and related
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …

Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE ε4: the Cardiovascular Health Study Cognition Study

F Irie, AL Fitzpatrick, OL Lopez, LH Kuller… - Archives of …, 2008 - jamanetwork.com
Background Diabetes and the apolipoprotein E ε4 allele (APOEε4) increase the risk for
Alzheimer disease (AD). We hypothesize thatAPOEε4 may modify the risk for AD in …

[HTML][HTML] A comprehensive review of neuronal changes in diabetics

R Luna, RT Manjunatha, B Bollu, S Jhaveri… - Cureus, 2021 - ncbi.nlm.nih.gov
There has been an exponential rise in diabetes mellitus (DM) cases on a global scale.
Diabetes affects almost every system of the body, and the nervous system is no exception …

[HTML][HTML] Cognitive dysfunctions in individuals with diabetes mellitus

HG Kim - Yeungnam University journal of medicine, 2019 - synapse.koreamed.org
Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive
dysfunctions. The pathophysiology underlying this complication is not well understood. Type …