Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management

CX Ma, XN Ma, CH Guan, YD Li, D Mauricio… - Cardiovascular …, 2022 - Springer
Cardiovascular diseases (CVDs) are the main cause of death among patients with type 2
diabetes mellitus (T2DM), particularly in low-and middle-income countries. To effectively …

Role of insulin in health and disease: an update

MS Rahman, KS Hossain, S Das, S Kundu… - International journal of …, 2021 - mdpi.com
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Diabetes mellitus: an overview of the types, symptoms, complications and management.

L Cloete - Nursing Standard (Royal College of Nursing (Great …, 2021 - europepmc.org
The incidence of diabetes mellitus is rapidly increasing, and this condition often results in
significant metabolic disease and severe complications. Nurses have a crucial role in …

Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation

AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - Am Heart Assoc
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Continuous self‐oxygenated double‐layered hydrogel under natural light for real‐time infection monitoring, enhanced photodynamic therapy, and hypoxia relief in …

Z Zhu, L Wang, Y Peng, X Chu, L Zhou… - Advanced Functional …, 2022 - Wiley Online Library
The human health is still threatened by refractory keratitis and diabetic foot ulcers caused by
bacterial infections, hypoxia, and chronic inflammation, so that patients are exposed to the …

[HTML][HTML] The role of estrogen in insulin resistance: a review of clinical and preclinical data

M De Paoli, A Zakharia, GH Werstuck - The American journal of pathology, 2021 - Elsevier
Insulin resistance results when peripheral tissues, including adipose, skeletal muscle, and
liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This …

Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues

Z Song, AM Xiaoli, F Yang - Nutrients, 2018 - mdpi.com
De novo lipogenesis (DNL) is a complex and highly regulated process in which
carbohydrates from circulation are converted into fatty acids that are then used for …