The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

Extracellular vesicles (EVs) are secreted by myriad cells in culture and also by unicellular
organisms, and their identification in mammalian fluids suggests that EV release also occurs …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to the progressive decline of motor control due to the loss of dopaminergic neurons in the …

Protein disulfide isomerases are thiol oxidoreductase chaperones from thioredoxin
superfamily. As redox folding catalysts from the endoplasmic reticulum (ER), their roles in …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular
and molecular mechanisms yet to be fully described. Mutations in a number of genes …