Acetylcholine (AC h) plays an important role in memory function and has been implicated in
aging‐related dementia, in which the impairment of hippocampus‐dependent learning …

Objective: To examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and
neurologic conditions, such as Alzheimer's disease (AD). The rationale for inhibiting …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Background The study aimed to validate previously discovered plasma biomarkers
associated with AD, using a design based on imaging measures as surrogate for disease …

Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in
Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular …

Objectives Apolipoproteins have recently been implicated in the etiology of Alzheimer's
disease (AD). In particular, Apolipoprotein J (ApoJ or clusterin) has been proposed as a …

The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for
Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid-β …

The apolipoprotein E (ApoE) ε4 allele is the strongest risk factor of sporadic Alzheimer's
disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2 …

The senescence accelerate mouse P8 (SAMP8) is an excellent model of early learning and
memory problems. A number of studies have shown that it has cholinergic deficits, oxidative …

Profound synaptic dysfunction contributes to early loss of short-term memory in Alzheimer's
disease. This study was set up to analyze possible neuroprotective effects of two dual …