Intermittent lead exposure induces behavioral and cardiovascular alterations associated with neuroinflammation

L Shvachiy, Â Amaro-Leal, TF Outeiro, I Rocha… - Cells, 2023 - mdpi.com
The nervous system is the primary target for lead exposure and the developing brain
appears to be especially susceptible, namely the hippocampus. The mechanisms of lead …

[HTML][HTML] Interplay and long-lasting effects of maternal low-level Pb, Hg, and Cd exposures on offspring cognition

L Ouyang, Q Li, S Yang, L Yan, J Li, X Wan… - Ecotoxicology and …, 2024 - Elsevier
Abstract Lead (Pb), mercury (Hg), and cadmium (Cd) are prevalent and persistent
environmental contaminants, causing detrimental effects on millions of individuals …

Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures

L Shvachiy, Â Amaro-Leal, F Machado, I Rocha… - Biomedicines, 2024 - mdpi.com
Lead exposure is a significant health concern, ranking among the top 10 most harmful
substances for humans. There are no safe levels of lead exposure, and it affects multiple …

[HTML][HTML] Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model

 Amaro-Leal, AI Afonso, F Machado, L Shvachiy… - Biology, 2024 - mdpi.com
Cognitive impairment and anxiety are common side effects of chemotherapy, particularly
with the use of doxorubicin (DOX), known as “chemobrain”. This study aimed to examine the …

Chronic lead exposure disrupts neurometabolic activity in mouse brain: An ex vivo 1H-[13C]-NMR study

KS Varadarajan, P Bagga, A Ramesh, AN Chugani… - Neurotoxicology, 2023 - Elsevier
Lead poisoning has been identified as a problem in adults as well as in children. Chronic
exposure to lead has been implicated in neurological disorders such as amyotrophic lateral …

Lead as a toxic environmental toxicant in models of synucleinopathies

L Shvachiy, A Amaro-Leal, F Machado, I Rocha… - bioRxiv, 2024 - biorxiv.org
Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to
environmental contamination and significant health concerns. Lead affects various body …