Transmembrane potassium (K) gradients are key determinants of membrane potential that
can modulate action potentials, control muscle contractility, and influence ion channel and …

Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …

Aim The kaliuretic action of the renin–angiotensin–aldosterone system (RAAS) is well
established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is …

Arterial hypertension is a serious medical condition that significantly increases the risks of
heart, brain, kidney, and other diseases affecting 1.28 billion adults worldwide. The authors …

Objective Glomerular filtration rate (GFR) is a key indicator of renal function. In both clinical
practice and pre-clinical research, serum levels of endogenous filtration markers, such as …

Shortly after the discovery of aldosterone (1), Jerome Conn and colleagues characterized a
form of hypertension, indelibly associated with Conn's name, that exhibited excessive …

Our body is constantly exposed to a multitude of challenges, which could cause
disturbances to the internal milieu. An example is food intake. Food provides our body with …

Sir Isaac Newton's 1686" Philosophiae Naturalis Principia Mathematica"[1] has repeatedly,
and notably by biomedical scientists, been cited as the most influential single piece of …