The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Large-scale sequencing of cancer genomes has uncovered thousands of DNA alterations,
but the functional relevance of the majority of these mutations to tumorigenesis is unknown …

Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse …

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential
for many physiological processes, and aberrant angiogenesis contributes to some of the …

Aggressive primary tumors express transcriptional signatures that correlate with their
metastatic propensity. A number of these signatures have been deployed in the clinic as risk …

Retinopathy of prematurity causes visual impairment due to destructive neoangiogenesis
after degeneration of the retinal microvasculature. This study was aimed at analyzing …

The tumor microenvironment, including stromal myofibroblasts and associated matrix
proteins, regulates cancer cell invasion and proliferation. Here, we report that neuropilin-1 …

Abstract Class 3 semaphorins (SEMA3) were first identified as glycoproteins that negatively
mediate neuronal guidance by binding to neuropilin and repelling neurons away from the …