Primary cilia as dynamic and diverse signalling hubs in development and disease

P Mill, ST Christensen, LB Pedersen - Nature Reviews Genetics, 2023 - nature.com
Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Architecture of the IFT ciliary trafficking machinery and interplay between its components

K Nakayama, Y Katoh - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …

Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia

T Kanamaru, A Neuner, B Kurtulmus… - The EMBO Journal, 2022 - embopress.org
Primary cilia are antenna‐like organelles required for signalling transduction. How cilia
structure is mechanistically maintained at steady‐state to promote signalling is largely …

Acute inhibition of heterotrimeric kinesin-2 function reveals mechanisms of intraflagellar transport in mammalian cilia

MF Engelke, B Waas, SE Kearns, A Suber, A Boss… - Current Biology, 2019 - cell.com
The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by
kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric …

Proteins that control the geometry of microtubules at the ends of cilia

P Louka, KK Vasudevan, M Guha, E Joachimiak… - Journal of Cell …, 2018 - rupress.org
Cilia, essential motile and sensory organelles, have several compartments: the basal body,
transition zone, and the middle and distal axoneme segments. The distal segment …

Insights into photoreceptor ciliogenesis revealed by animal models

W Baehr, C Hanke-Gogokhia, A Sharif, M Reed… - Progress in retinal and …, 2019 - Elsevier
Photoreceptors are polarized neurons, with very specific subcellular compartmentalization
and unique requirements for protein expression and trafficking. Each photoreceptor contains …

Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins

SK Morthorst, ST Christensen… - The FEBS journal, 2018 - Wiley Online Library
Primary cilia are antenna‐like sensory organelles that regulate a substantial number of
cellular signalling pathways in vertebrates, both during embryonic development as well as in …

Ciliary kinesins beyond IFT: cilium length, disassembly, cargo transport and signalling

ML Reilly, A Benmerah - Biology of the Cell, 2019 - Wiley Online Library
Cilia and flagella are microtubule‐based antenna which are highly conserved among
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …

Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period

Q Qiu, Y Wu, L Ma, W Xu, M Hills Jr, V Ramalingam… - elife, 2021 - elifesciences.org
Animals possess an inborn ability to recognize certain odors to avoid predators, seek food,
and find mates. Innate odor preference is thought to be genetically hardwired. Here we …

Insights gained from zebrafish models for the ciliopathy Joubert syndrome

TDS Rusterholz, C Hofmann… - Frontiers in …, 2022 - frontiersin.org
Cilia are quasi-ubiquitous microtubule-based sensory organelles, which play vital roles in
signal transduction during development and cell homeostasis. Dysfunction of cilia leads to a …