Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Ionic-liquid-mediated extraction and separation processes for bioactive compounds: past, present, and future trends

SPM Ventura, FA e Silva, MV Quental… - Chemical …, 2017 - ACS Publications
Ionic liquids (ILs) have been proposed as promising media for the extraction and separation
of bioactive compounds from the most diverse origins. This critical review offers a …

The role of ionic liquids in the pharmaceutical field: An overview of relevant applications

SN Pedro, CS R. Freire, AJD Silvestre… - International journal of …, 2020 - mdpi.com
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to
solid-state pharmaceuticals demand for effective solutions. To overcome some of these …

General principles and strategies for salting-out informed by the Hofmeister series

AM Hyde, SL Zultanski, JH Waldman… - … Process Research & …, 2017 - ACS Publications
Overarching principles for salting-out extraction are long-established but poorly
disseminated. We highlight the opportunity for more widespread application of this …

[HTML][HTML] Solvent developments for liquid-liquid extraction of carboxylic acids in perspective

LMJ Sprakel, B Schuur - Separation and purification technology, 2019 - Elsevier
The growing desire to produce organic acids through fermentative routes, as a starting point
for bio-based plastics, has revived the scientific attention on carboxylic acid removal from …

Therapeutic role of deep eutectic solvents based on menthol and saturated fatty acids on wound healing

JM Silva, CV Pereira, F Mano, E Silva… - ACS Applied Bio …, 2019 - ACS Publications
The breakthroughs achieved in green solvents promote the emergence of therapeutic deep
eutectic solvents (THEDES), which possess intriguing possible applications in the …

Applications of ionic liquids in the food and bioproducts industries

AAC Toledo Hijo, GJ Maximo, MC Costa… - ACS Sustainable …, 2016 - ACS Publications
Ionic liquids (ILs) have been extensively used in many research and industry fields,
including chemical and pharmaceutical applications. Nevertheless, during past years, some …

Do Ionic Liquids Exhibit the Required Characteristics to Dissolve, Extract, Stabilize, and Purify Proteins? Past-Present-Future Assessment

P Bharmoria, AA Tietze, D Mondal, TS Kang… - Chemical …, 2024 - ACS Publications
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …

Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems

SN Pedro, MG Freire, CSR Freire… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Deep eutectic solvents comprising or acting as solvents of active
pharmaceutical ingredients (API-DES) emerged as promising alternatives to improve …

Selective enzymes separation from the fermentation broth of Yarrowia lipolytica using aqueous two-phase system based on quaternary ammonium compounds

FS Buarque, A Carniel, BD Ribeiro… - Separation and …, 2023 - Elsevier
Aqueous two-phase systems (ATPS) are considered efficient and sustainable downstream
processing techniques in extracting and separating enzymes. In this work, we evaluated the …