The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Background Our understanding of the pathophysiology of the COVID-19 manifestations and
evolution has improved over the past 10 months, but the reasons why evolution is more …

The aim of the present study was to compare different diets used to induce obesity in a head-
to-head manner with a focus on insulin resistance and vascular dysfunction. Male C57BL/6J …

Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …

Non-alcoholic fatty liver disease (NAFLD) represents a predominant hepatopathy that is
rapidly becoming the most common cause of hepatocellular carcinoma worldwide. The …

Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability
is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

Obesity alters levels of pituitary hormones that govern hepatic immune-metabolic
homeostasis, dysregulation of which leads to nonalcoholic fatty liver disease (NAFLD) …

Here we review how immune activation and insulin resistance contribute to the metabolic
alterations observed in HIV-infected patients, and how these alterations increase the risk of …

Introduction The timing of maternal exposure to air pollution is crucial to define metabolic
changes in the offspring. Here we aimed to determine the most critical period of maternal …