Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer
characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable …

Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer
cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication …

Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer
progression. Tumour induced beige/brown adipose tissue differentiation contributes to the …

Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Malignant pleural mesothelioma (MPM) is a highly invasive form of lung cancer that
adversely affects the pleural and other linings of the lungs. MPM is a very aggressive tumor …

Dysregulation of the PI3K/PTEN pathway is a frequent event in cancer, and PIK3CA and
PTEN are the most commonly mutated genes after TP53. PIK3R1 is the predominant …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression
predominantly by inhibiting transcription and/or promoting degradation of target mRNAs also …

Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

MicroRNAs (miRNAs) have emerged as critical modulators of ECs function and play a vital
role in the development of cardiovascular disease. Among them, miR-126 is a crucial …