The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics
The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …
“-omics”, including glycomics, working with a large amount of data regarding human and …
DNA mismatches reveal conformational penalties in protein–DNA recognition
Transcription factors recognize specific genomic sequences to regulate complex gene-
expression programs. Although it is well-established that transcription factors bind to specific …
expression programs. Although it is well-established that transcription factors bind to specific …
Regulation of cellular miRNA expression by human papillomaviruses
ZM Zheng, X Wang - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2011 - Elsevier
High-risk HPV infection leads to aberrant expression of cellular oncogenic and tumor
suppressive miRNAs. A large number of these miRNA genes are downstream targets of the …
suppressive miRNAs. A large number of these miRNA genes are downstream targets of the …
How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
The tumor suppressive transcription factor p53 regulates a wide array of cellular processes
that confer upon cells an essential protection against cancer development. Wild-type p53 …
that confer upon cells an essential protection against cancer development. Wild-type p53 …
A molecular mechanism for the “digital” response of p53 to stress
J Safieh, A Chazan, H Saleem, P Vyas… - Proceedings of the …, 2023 - National Acad Sciences
The tumor suppressor protein p53 accumulates in response to cellular stress and
consequently orchestrates the expression of multiple genes in a p53-level and time …
consequently orchestrates the expression of multiple genes in a p53-level and time …
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain
O Laptenko, I Shiff, W Freed-Pastor, A Zupnick… - Molecular cell, 2015 - cell.com
DNA binding by numerous transcription factors including the p53 tumor suppressor protein
constitutes a vital early step in transcriptional activation. While the role of the central core …
constitutes a vital early step in transcriptional activation. While the role of the central core …
Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
TP53 is a transcription factor that controls multiple cellular processes, including cell cycle
arrest, DNA repair and apoptosis. The relation between TP53 binding site architecture and …
arrest, DNA repair and apoptosis. The relation between TP53 binding site architecture and …
Adaptive homeostasis and the p53 isoform network
All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …
Characterization of the p53 cistrome–DNA binding cooperativity dissects p53's tumor suppressor functions
K Schlereth, C Heyl, AM Krampitz, M Mernberger… - PLoS …, 2013 - journals.plos.org
p53 protects us from cancer by transcriptionally regulating tumor suppressive programs
designed to either prevent the development or clonal expansion of malignant cells. How p53 …
designed to either prevent the development or clonal expansion of malignant cells. How p53 …