Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …

A number of widespread and devastating chronic diseases, including atherosclerosis, type 2
diabetes, and Alzheimer's disease, have a pathophysiologically important inflammatory …

Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …

Phagocytes orchestrate acute inflammation and host defense. Here we carried out lipid
mediator (LM) metabololipidomics profiling distinct phagocytes: neutrophils (PMN), apoptotic …

The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …