Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Localization and translation of mRNAs within different subcellular domains provides an
important mechanism to spatially and temporally introduce new proteins in polarized cells …

Critical functions of intra-axonally synthesized proteins are thought to depend on regulated
recruitment of mRNA from storage depots in axons. Here we show that axotomy of …

Subcellular localization of mRNA enables compartmentalized regulation within large cells.
Neurons are the longest known cells; however, so far, evidence is lacking for an essential …

Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control
mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an …

In multiple cell types, mRNAs are transported to subcellular compartments, where local
translation enables rapid, spatially localized, and specific responses to external stimuli …

Messenger RNA (mRNA) can be transported and targeted to different subcellular
compartments and locally translated. Local translation is an evolutionally conserved …

Localized translation of axonal mRNA s contributes to developmental and regenerative axon
growth. Although untranslated regions (UTRs) of many different axonal mRNA s appear to …

Investigating the molecular mechanisms governing developmental axon growth has been a
useful approach for identifying new strategies for boosting axon regeneration after injury …

Increased mTOR activity has been shown to enhance regeneration of injured axons by
increasing neuronal protein synthesis, while PTEN signaling can block mTOR activity to …