Over the last decade, the field of hereditary haematological malignancy syndromes
(HHMSs) has gained increasing recognition among clinicians and scientists worldwide …

First reported in 1999, germline runt-related transcription factor 1 (RUNX1) mutations are a
well-established cause of familial platelet disorder with predisposition to myeloid …

Simple Summary Pathogenic germline variants affecting RUNX1 are associated with
qualitative and/or quantitative platelet defects, and predispose to hematologic malignancies …

Disease-initiating mutations in the transcription factor RUNX1 occur as germline and
somatic events that cause leukemias with particularly poor prognosis. However, the role of …

A heterogeneous genetic subtype of B-cell precursor acute lymphoblastic leukemia is driven
by constitutive kinase-activation, including patients with JAK2 fusions. In our study, we …

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) is
an autosomal dominant condition characterized by abnormal platelet number and function …

The mechanisms by which patients with RUNX 1 familial platelet disorder with propensity to
myeloid malignancies (FPDMM) develop myeloid malignancies (MM) are not fully …

Background Rapid progression contributes to treatment failure in anaplastic thyroid
carcinoma (ATC) patients. In a preliminary study, we demonstrated that some hematopoietic …

RUNX1 associated familial platelet disorder (FPD) is a rare autosomal dominant
hematologic disorder characterized by thrombocytopenia and/or altered platelet function …

Inherited hematologic malignancies are linked to a heterogenous group of genes,
knowledge of which is rapidly expanding using panel-based next-generation sequencing …