Genome-resolved metagenomics: a game changer for microbiome medicine

N Kim, J Ma, W Kim, J Kim, P Belenky… - Experimental & Molecular …, 2024 - nature.com
Recent substantial evidence implicating commensal bacteria in human diseases has given
rise to a new domain in biomedical research: microbiome medicine. This emerging field …

<? mode longmeta?> SPIRE: a Searchable, Planetary-scale mIcrobiome REsource

TSB Schmidt, A Fullam, P Ferretti, A Orakov… - Nucleic Acids …, 2024 - academic.oup.com
Meta'omic data on microbial diversity and function accrue exponentially in public
repositories, but derived information is often siloed according to data type, study or sampled …

Generation of accurate, expandable phylogenomic trees with uDance

M Balaban, Y Jiang, Q Zhu, D McDonald… - Nature …, 2024 - nature.com
Phylogenetic trees provide a framework for organizing evolutionary histories across the tree
of life and aid downstream comparative analyses such as metagenomic identification …

Challenges in computational discovery of bioactive peptides in'omics data

LP Coelho, CD Santos‐Júnior… - …, 2024 - Wiley Online Library
Peptides have a plethora of activities in biological systems that can potentially be exploited
biotechnologically. Several peptides are used clinically, as well as in industry and …

A fast comparative genome browser for diverse bacteria and archaea

MN Price, AP Arkin - Plos one, 2024 - journals.plos.org
Genome sequencing has revealed an incredible diversity of bacteria and archaea, but there
are no fast and convenient tools for browsing across these genomes. It is cumbersome to …

BGCFlow: systematic pangenome workflow for the analysis of biosynthetic gene clusters across large genomic datasets

M Nuhamunada, OS Mohite, PV Phaneuf… - Nucleic Acids …, 2024 - academic.oup.com
Genome mining is revolutionizing natural products discovery efforts. The rapid increase in
available genomes demands comprehensive computational platforms to effectively extract …

Getting your money's worth: Testing the value of data for hydrological model calibration

J Seibert, FM Clerc‐Schwarzenbach… - Hydrological …, 2024 - Wiley Online Library
Despite the big data era, observational data continue to be a limiting factor in the
environmental sciences. To collect the most informative field data, studies on the value of …

Statistical prediction of microbial metabolic traits from genomes

Z Li, A Selim, S Kuehn - PLOS Computational Biology, 2023 - journals.plos.org
The metabolic activity of microbial communities is central to their role in biogeochemical
cycles, human health, and biotechnology. Despite the abundance of sequencing data …

Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut

Y Cherrak, MA Salazar, N Näpflin, L Malfertheiner… - Nature …, 2024 - nature.com
Resource competition is a driver of gut microbiota composition. Bacteria can outcompete
metabolically similar rivals through the limitation of shared growth-fuelling nutrients. The …

The mOTUs online database provides web-accessible genomic context to taxonomic profiling of microbial communities

M Dmitrijeva, HJ Ruscheweyh, L Feer, K Li… - Nucleic Acids …, 2024 - academic.oup.com
Determining the taxonomic composition (taxonomic profiling) is a fundamental task in
studying environmental and host-associated microbial communities. However, genome …