One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

Cancer cells possess metabolic properties that are different from those of benign cells. p21,
encoded by CDKN1A gene, also named p21 Cip1/WAF1, was first identified as a cyclin …

Relative quiescence is a defining characteristic of hematopoietic stem cells, while their
progeny have dramatic proliferative ability and inexorably move toward terminal …

OBJECTIVE: Recent evidence suggests that hematopoietic stem cells (HSCs) in the bone
marrow (BM) are located in areas where the environment is hypoxic. Although previous …

Hematopoiesis during steady state conditions is regulated and finely tuned by a network of
cytokines and their effects on hematopoietic stem and progenitor cells and on accessory …

Although the roles of survivin in control of cancer cell division and apoptosis as well as
targeting survivin for cancer therapeutics have been extensively explored and reviewed, the …

Notch signaling is implicated in stem cell self-renewal, differentiation, and other
developmental processes, and the Drosophila hairy and enhancer of split (HES) 1 basic …

Allogeneic transplantation with umbilical cord blood (UCB) is limited in adult recipients by a
low CD34+ cell dose. Clinical trials incorporating cytokine-based UCB in vitro expansion …

The cell cycle behavior of hematopoietic cells varies from extended quiescence to
spectacular proliferation. Cell cycle regulators choreograph these transitions through …

The zinc finger transcription factor GATA-2 has been implicated in the regulation of
hematopoietic stem cells. Herein, we explored the role of GATA-2 as a candidate regulator …