Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

Nanomaterials in tumor immunotherapy: new strategies and challenges

X Zhu, S Li - Molecular Cancer, 2023 - Springer
Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune
responses of the body. It has become another important modality of anti-tumor therapy with …

Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment

H Zhang, S Li, D Wang, S Liu, T Xiao, W Gu, H Yang… - Biomarker …, 2024 - Springer
Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …

Ultrafast self-assembled supramolecular nanoparticles for enhanced chemodynamic therapy and ferroptosis through lactic acid metabolism regulation

Q Meng, J Tan, W Tong, C Chen, Z Liu, S Liu… - Chemical Engineering …, 2023 - Elsevier
Chemodynamic therapy (CDT) is an antitumor strategy based on the Fenton response.
However, the mild acidity in the tumor microenvironment (TME) limits the efficiency of the …

Nanomaterials: breaking through the bottleneck of tumor immunotherapy

Y Kang, S Li - International Journal of Biological Macromolecules, 2023 - Elsevier
Immunotherapy exerts its excellent anti-tumor effects by stimulating and enhancing the
immune response of the body, and has become another important class of anti-tumor …

A novel tyrosine tRNA-derived fragment, tRFTyr, induces oncogenesis and lactate accumulation in LSCC by interacting with LDHA

R Zhao, Z Yang, B Zhao, W Li, Y Liu, X Chen… - Cellular & Molecular …, 2023 - Springer
Background Transfer (t) RNA-derived small RNA (tsRNA), generated from precursor or
mature tRNA, is a new type of small non-coding RNA (sncRNA) that has recently been …

Unlocking the multifaceted molecular functions and diverse disease implications of lactylation

F Jing, J Zhang, H Zhang, T Li - Biological Reviews, 2024 - Wiley Online Library
In recent years, a significant breakthrough has emerged in biology, the identification of
lactylation, a novel post‐translational process. This intriguing modification is not limited to a …

Current advances on nanomaterials interfering with lactate metabolism for tumor therapy

Q Cheng, XL Shi, QL Li, L Wang, Z Wang - Advanced Science, 2024 - Wiley Online Library
Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

S He, X Jia, S Feng, J Hu - Small, 2023 - Wiley Online Library
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity,
nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor …

Histone modification: biomarkers and potential therapies in colorectal cancer

X An, X Lan, Z Feng, X Li, Q Su - Annals of Human Genetics, 2023 - Wiley Online Library
The complex mechanism of colorectal cancer development is closely associated with
epigenetic modifications and is caused by overexpression and/or inactivation of oncogenes …