The biosynthesis of enzymatically oxidized lipids

AA Hajeyah, WJ Griffiths, Y Wang, AJ Finch… - Frontiers in …, 2020 - frontiersin.org
Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Bacterial catabolism of lignin‐derived aromatics: new findings in a recent decade: update on bacterial lignin catabolism

N Kamimura, K Takahashi, K Mori… - Environmental …, 2017 - Wiley Online Library
Lignin is the most abundant phenolic polymer; thus, its decomposition by microorganisms is
fundamental to carbon cycling on earth. Lignin breakdown is initiated by depolymerization …

Complete biosynthesis of the potent vaccine adjuvant QS-21

LBB Martin, S Kikuchi, M Rejzek, C Owen… - Nature Chemical …, 2024 - nature.com
QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean
soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus …

11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action

K Chapman, M Holmes, J Seckl - Physiological reviews, 2013 - journals.physiology.org
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Astaxanthin: a potential mitochondrial‐targeted antioxidant treatment in diseases and with aging

M Sztretye, B Dienes, M Gönczi… - Oxidative Medicine …, 2019 - Wiley Online Library
Oxidative stress is characterized by an imbalance between prooxidant and antioxidant
species, leading to macromolecular damage and disruption of redox signaling and cellular …

The biosynthesis of thymol, carvacrol, and thymohydroquinone in Lamiaceae proceeds via cytochrome P450s and a short-chain dehydrogenase

ST Krause, P Liao, C Crocoll… - Proceedings of the …, 2021 - National Acad Sciences
Thymol and carvacrol are phenolic monoterpenes found in thyme, oregano, and several
other species of the Lamiaceae. Long valued for their smell and taste, these substances also …

Aldehyde toxicity and metabolism: the role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis

A Ahmed Laskar, H Younus - Drug metabolism reviews, 2019 - Taylor & Francis
Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …

Signatures of archaic adaptive introgression in present-day human populations

F Racimo, D Marnetto… - Molecular biology and …, 2017 - academic.oup.com
Comparisons of DNA from archaic and modern humans show that these groups interbred,
and in some cases received an evolutionary advantage from doing so. This process …

Novel mechanisms for DHEA action

RA Prough, BJ Clark, CM Klinge - Journal of molecular …, 2016 - jme.bioscientifica.com
Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal
cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the …

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis

E Vilardo, C Nachbagauer, A Buzet… - Nucleic acids …, 2012 - academic.oup.com
Transfer RNAs (tRNAs) reach their mature functional form through several steps of
processing and modification. Some nucleotide modifications affect the proper folding of …