Bacterial extracellular vesicles and their interplay with the immune system

E Doré, E Boilard - Pharmacology & Therapeutics, 2023 - Elsevier
The mammalian intestinal tract harbors trillions of microorganisms confined within this space
by mucosal barriers. Despite these barriers, bacterial components may still be found …

Modulation of immunity by the secreted phospholipase A2 family

M Murakami, H Sato, Y Taketomi - Immunological reviews, 2023 - Wiley Online Library
Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

[HTML][HTML] Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota

Y Miki, Y Taketomi, Y Kidoguchi, K Yamamoto… - JCI insight, 2022 - ncbi.nlm.nih.gov
Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted
phospholipase A 2 (sPLA 2-IIA) prevents bacterial infection by degrading bacterial …

Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation

M Murakami, R Takamiya, Y Miki, N Sugimoto… - Biochemical …, 2022 - Elsevier
Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …

Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology

Y Taketomi, M Murakami - Frontiers in Immunology, 2022 - frontiersin.org
Lipids play fundamental roles in life as an essential component of cell membranes, as a
major source of energy, as a body surface barrier, and as signaling molecules that transmit …

Faecalibacterium prausnitzii Supplementation Prevents Intestinal Barrier Injury and Gut Microflora Dysbiosis Induced by Sleep Deprivation

X Wang, Y Li, X Wang, R Wang, Y Hao, F Ren, P Wang… - Nutrients, 2024 - mdpi.com
Sleep deprivation (SD) leads to impaired intestinal barrier function and intestinal flora
disorder, especially a reduction in the abundance of the next generation of probiotic …

Emerging roles of host and microbial bioactive lipids in inflammatory bowel diseases

H Kayama, K Takeda - European Journal of Immunology, 2023 - Wiley Online Library
The intestinal tract harbors diverse microorganisms, host‐and microbiota‐derived
metabolites, and potentially harmful dietary antigens. The epithelial barrier separates the …

Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion

AC Duchez, S Fauteux-Daniel, C Sut… - Frontiers in …, 2023 - frontiersin.org
Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting
severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions …

[HTML][HTML] Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of α …

L Cui, H Zeng, M Hou, Z Li, C Mu, W Zhu, S Hang - Animal Nutrition, 2023 - Elsevier
Alternatives to antibiotics for preventing bacteria-induced inflammation in early-weaned farm
animals are sorely needed. Our previous study showed that Lactiplantibacillus plantarum …