Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

The immune system's complexity and ongoing evolutionary struggle against deleterious
pathogens underscore the value of vaccination technologies, which have been bolstering …

Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

The secretory granules from the mammalian endocrine system are functional amyloids that
act as dynamic depots to store and release protein hormones into the bloodstream. The …

Conspectus Insulin has remained indispensable in the treatment of diabetes since it was first
discovered in 1921. Unlike small molecular drugs, insulin and other protein drugs are prone …

Osmolytes are small organic compounds accumulated at higher concentrations in the cell
under various stress conditions like high temperature, high salt, high pressure, etc …

Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is
challenging due to generally poor cell membrane permeation and endolysosomal …

Developing stabilizers that protect proteins from denaturation under stress, and are easy to
remove from solutions, is a challenge in protein therapeutics. In this study, micelles made of …

Protection of proteins is of great significance since external stimuli can cause denaturation
due to aggregation. Herein, a series of well-defined cationic trehalose-glycopolypeptides …