Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

Background Gliomas are the most common malignant primary brain tumours with a highly
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Plant resource allocation patterns often reveal tradeoffs that favor growth (G) over defense
(D), or vice versa. Ecologists most often explain G–D tradeoffs through principles of …

Lysosomes are the primary degradative compartment within cells and there have been
significant advances over the past decade toward understanding how lysosome …

Mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating
anabolic and catabolic processes in response to environmental cues, including nutrients …

Cholesterol contributes to the structural basis of biological membranes and functions as a
signaling molecule, whose dysregulation has been associated with various human …

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …