Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding
enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to …

Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

To achieve homeostasis, cells evolved dynamic and self-regulating quality control
processes to adapt to new environmental conditions and to prevent prolonged damage. We …

Autophagy is fundamental for cell and organismal health. Two types of autophagy are
conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …