Impact of childhood malnutrition on host defense and infection

MK Ibrahim, M Zambruni, CL Melby… - Clinical microbiology …, 2017 - Am Soc Microbiol
The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …

[HTML][HTML] Redox control of protein degradation

M Pajares, N Jiménez-Moreno, IHK Dias, B Debelec… - Redox biology, 2015 - Elsevier
Intracellular proteolysis is critical to maintain timely degradation of altered proteins including
oxidized proteins. This review attempts to summarize the most relevant findings about …

Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice

WJ Li, L Li, WY Zhen, LF Wang, M Pan, JQ Lv… - Food and Chemical …, 2017 - Elsevier
Abstract Ganoderma atrum polysaccharide (PSG-1) is a bioactive compound with
antioxidant and immunomodulatory activities. The aim of this study was to determine the …

Thymus, undernutrition, and infection: approaching cellular and molecular interactions

W Savino, J Durães, C Maldonado-Galdeano… - Frontiers in …, 2022 - frontiersin.org
Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …

Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production

L Amorim Sacramento, C Gonzalez-Lombana… - PLoS …, 2024 - journals.plos.org
Protein-energy malnutrition (PEM) is a risk factor for developing visceral leishmaniasis (VL).
While nutrient deficiency can impair immunity, its mechanistic impact on protective adaptive …

The effect of malnutrition on the infectious outcomes of hospitalized patients with cirrhosis: analysis of the 2011–2017 hospital data

DU Lee, GH Fan, RR Ahern… - European journal of …, 2021 - journals.lww.com
Background In patients with cirrhosis, there is a clinical concern that the development of
protein-calorie malnutrition will affect the immune system and predispose these patients to …

Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected …

EY Osorio, A Uscanga-Palomeque… - PLoS neglected …, 2023 - journals.plos.org
People are infected with Leishmania donovani when the parasite is deposited in the dermis
during the blood meal of the sand fly vector. Most infected people develop a subclinical …

Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies

H Michael, JO Amimo, G Rajashekara, LJ Saif… - Frontiers in …, 2022 - frontiersin.org
Malnutrition refers to inadequate energy and/or nutrient intake. Malnutrition exhibits a
bidirectional relationship with infections whereby malnutrition increases risk of infections that …

The binomial parasite-host immunity in the healing process and in reactivation of human tegumentary leishmaniasis

F Conceição-Silva, J Leite-Silva… - Frontiers in …, 2018 - frontiersin.org
Leishmaniasis is a vector-borne infectious disease caused by different species of protozoa
from the Leishmania genus. Classically, the disease can be classified into two main clinical …

Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum

M Losada-Barragán, A Umaña-Pérez… - Scientific Reports, 2017 - nature.com
Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has
been considered a primary risk factor for the development of clinical visceral leishmaniasis …