The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

BACKGROUND Two developments in distinct fields are converging to create interest in
discovering small molecules from the human microbiome. First, the use of genomics to guide …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Secondary metabolites profoundly affect microbial physiology, metabolism and stress
responses. Increasing evidence suggests that these molecules can modulate microbial …

Antagonistic bacterial interactions often rely on antimicrobial bacteriocins, which attack only
a narrow range of target bacteria. However, antimicrobials with broader activity may be …

Microorganisms reside in diverse environmental communities where interactions become
indispensable due to close physical associations. These interactions are driven by chemical …

Lactococcus lactis is one of the most important micro-organisms in the dairy industry for the
fermentation of cheese and buttermilk. Besides the conversion of lactose to lactate it is …

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the
oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might …

Mutanobactin D is a non-ribosomal, cyclic peptide isolated from Streptococcus mutans and
shows activity reducing yeast-to-hyphae transition as well as biofilm formation of the …