[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Linking stress and immunity: Immunoglobulin A as a non-invasive physiological biomarker in animal welfare studies

M Staley, MG Conners, K Hall, LJ Miller - Hormones and Behavior, 2018 - Elsevier
As the animal welfare community strives to empirically assess how care and management
practices can help maintain or even enhance welfare, the development of tools for non …

Efficacy of a synthetic peptide Chlamydia pecorum major outer membrane protein vaccine in a wild koala (Phascolarctos cinereus) population

SJ Simpson, DP Higgins, P Timms, VSA Mella… - Scientific Reports, 2023 - nature.com
Chlamydiosis is a significant disease affecting Eastern Australian koala (Phascolarctos
cinereus) populations, impacting individual animal welfare and fecundity and therefore …

Helping koalas battle disease – Recent advances in Chlamydia and koala retrovirus (KoRV) disease understanding and treatment in koalas

BL Quigley, P Timms - FEMS Microbiology Reviews, 2020 - academic.oup.com
The iconic Australian marsupial, the koala (Phascolarctos cinereus), has suffered dramatic
population declines as a result of habitat loss and fragmentation, disease, vehicle collision …

Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality

S Phillips, J Hanger, J Grosmaire, A Mehdi, M Jelocnik… - npj Vaccines, 2024 - nature.com
Abstract In 2022, the Australian Government listed the koala as endangered in several
states due to habitat destruction, traffic strikes, dog attacks, and Chlamydia pecorum …

The effect of Chlamydia infection on koala (Phascolarctos cinereus) semen quality

L Hulse, K Beagley, R Larkin, V Nicolson, J Gosálvez… - Theriogenology, 2021 - Elsevier
Although it is well established that chlamydial disease renders female koalas infertile, there
has been limited research on its effects on male koala fertility, specifically sperm quality. This …

Chlamydiae from Down Under: The Curious Cases of Chlamydial Infections in Australia

M Jelocnik - Microorganisms, 2019 - mdpi.com
In Australia, the most researched and perhaps the most successful chlamydial species are
the human pathogen Chlamydia trachomatis, animal pathogens Chlamydia pecorum and …

Optimising the short and long-term clinical outcomes for koalas (Phascolarctos cinereus) during treatment for chlamydial infection and disease

A Robbins, J Loader, P Timms, J Hanger - PLoS one, 2018 - journals.plos.org
Koalas (Phascolarctos cinereus) have suffered severe declines in the northern extent of their
range due to a variety of threats, including habitat destruction, trauma from cars and dogs …

Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses

S Phillips, D Madden, A Gillett, BL Quigley… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction This study employs bulk RNA sequencing, PCR, and ELISA assays to analyze
the pathological factors affecting the outcomes of C. pecorum ocular infections in koalas. It …

Therapeutic effect of a Chlamydia pecorum recombinant major outer membrane protein vaccine on ocular disease in koalas (Phascolarctos cinereus)

S Nyari, R Booth, BL Quigley, CA Waugh, P Timms - PLoS One, 2019 - journals.plos.org
Chlamydia pecorum is responsible for causing ocular infection and disease which can lead
to blindness in koalas (Phascolarctos cinereus). Antibiotics are the current treatment for …