Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications

F Safri, R Nguyen, S Zerehpooshnesfchi… - Cancer Gene …, 2024 - nature.com
Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

Recurrent hepatocellular carcinoma: patterns, detection, staging and treatment

D Papaconstantinou, DI Tsilimigras… - Journal of hepatocellular …, 2022 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths
worldwide with the incidence of recurrence being as high as 88% even among patients who …

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

J Krstic, I Reinisch, K Schindlmaier, M Galhuber… - Science …, 2022 - science.org
Cancer cells voraciously consume nutrients to support their growth, exposing metabolic
vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular …

Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment

J Ma, B Wang, H Shao, S Zhang, X Chen, F Li… - Drug Delivery, 2022 - Taylor & Francis
The systemic drug has historically been preferred for the treatment of the majority of
pathological conditions, particularly liver cancer. Indeed, this mode of treatment is …

Urea-functionalized organoselenium compounds as promising anti-HepG2 and apoptosis-inducing agents

FF El-Senduny, SM Shabana, D Rösel… - Future medicinal …, 2021 - Taylor & Francis
Hepatocellular carcinoma is a highly aggressive and difficult-to-treat type of cancer.
Incorporating urea functionality into the backbone of organoselenium compounds is …

Melatonin as an antitumor agent against liver cancer: an updated systematic review

P Fernández-Palanca, C Méndez-Blanco, F Fondevila… - Antioxidants, 2021 - mdpi.com
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic
and anti-inflammatory properties; reduced levels of this hormone are associated with higher …

Global pattern of trends in incidence, mortality, and mortality-to-incidence ratio rates related to liver cancer, 1990–2019: a longitudinal analysis based on the global …

M Amini, MA Looha, E Zarean, MA Pourhoseingholi - BMC Public Health, 2022 - Springer
Background Liver cancer (LC) is considered as one of the most dominant malignant tumors
which ranked 4th and 6th in terms of global mortality and incidence, respectively. This work …

[HTML][HTML] Metabolic primary liver cancer in adults: risk factors and pathogenic mechanisms

S Lugari, E Baldelli, A Lonardo - Metabolism and Target Organ …, 2023 - oaepublish.com
Primary liver cancer (PLC) is a heterogeneous group of disorders arising with the
background of chronic liver disease (CLD) owing to varying etiologies. PLC carries a high …

Development and evaluation of crocetin-functionalized pegylated magnetite nanoparticles for hepatocellular carcinoma

S Ibrahim, B Baig, S Hisaindee, H Darwish… - Molecules, 2023 - mdpi.com
Liver cancer remains among the leading causes of cancer-related deaths worldwide. This is
due to many reasons, including limitations of available drugs, late diagnosis due to the …

A systematic examination of burden of childhood cancers in 183 countries: estimates from GLOBOCAN 2018

R Sharma - European Journal of Cancer Care, 2021 - Wiley Online Library
Objective Childhood cancers are a significant cause of child deaths worldwide. This study
examines the burden of 33 childhood cancers in 183 countries. Methods The estimates of …