The CCR5 and CXCR4 coreceptors—central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

JP Moore, SG Kitchen, P Pugach… - AIDS research and human …, 2004 - liebertpub.com
In this review, we will discuss what is known, what is suspected, and what still remains
obscure about the central role played by coreceptor expression and usage in the …

Basics of the virology of HIV-1 and its replication

S Sierra, B Kupfer, R Kaiser - Journal of clinical virology, 2005 - Elsevier
Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

European guidelines on the clinical management of HIV-1 tropism testing

LPR Vandekerckhove, AMJ Wensing… - The Lancet infectious …, 2011 - thelancet.com
Viral tropism is the ability of viruses to enter and infect specific host cells and is based on the
ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended …

Novel insights into hepatitis C virus replication and persistence

R Bartenschlager, M Frese… - Advances in virus …, 2004 - books.google.com
C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural
Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …

Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5

MM Lederman, RS Veazey, R Offord, DE Mosier… - Science, 2004 - science.org
Topical agents, such as microbicides, that can protect against human immunodeficiency
virus (HIV) transmission are urgently needed. Using a chimeric simian/human …

V3: HIV's switch-hitter

O Hartley, PJ Klasse, QJ Sattentau… - AIDS Research & Human …, 2005 - liebertpub.com
The third variable region, V3, of the gp120 surface envelope glycoprotein is an
approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded …

Resistance to enfuvirtide, the first HIV fusion inhibitor

ML Greenberg, N Cammack - Journal of Antimicrobial …, 2004 - academic.oup.com
Fusion inhibitors are a new class of antiretroviral drugs (ARVs) for the treatment of human
immunodeficiency virus infection. Enfuvirtide is the first in this class to reach market …

Novel therapies based on mechanisms of HIV-1 cell entry

JM Kilby, JJ Eron - New England Journal of Medicine, 2003 - Mass Medical Soc
Inhibitors of human immunodeficiency virus type 1 (HIV-1) enzymes are central to the
treatment of HIV-1 infection, but the development of resistant viruses remains a problem …

Multistep entry of rotavirus into cells: a Versaillesque dance

S López, CF Arias - Trends in microbiology, 2004 - cell.com
Rotavirus entry into a cell is a complex multistep process in which different domains of the
rotavirus surface proteins interact with different cell surface molecules, which act as …

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue

Q Hu, I Frank, V Williams, JJ Santos, P Watts… - The Journal of …, 2004 - rupress.org
Identification of cellular factors involved in HIV-1 entry and transmission at mucosal surfaces
is critical for understanding viral pathogenesis and development of effective prevention …