Introduction: sickle cell disease (SCD) is a hereditary red blood cell disorder of public health
importance globally with Nigeria the epicenter zone in Africa. There is a paucity of …

The huge burden of sickle cell disease (SCD) coupled with a correspondingly high morbidity
and mortality, particularly in Sub-Saharan Africa, has made it really imperative to invest more …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Introduction: sickle cell disease and HIV infection are prevalent in sub-Saharan Africa. While
Haemoglobin S (HbS) contributes to significant morbidity and mortality in the homozygous or …

Introduction: Sickle cell disease is an inherited blood disorder with diverse clinical variability,
which predisposes patients to additional complications and frequent hospitalizations. Aims …

Sickle cell disease (SCD) is a widespread inherited blood disorder, which leaves lasting
effects on the health, social functioning, and finances of individuals, families, communities …

Background: Hemoglobinopathy is a group of inherited disorders characterized by structural
variations of the hemoglobin molecule; and sickle cell disease constitutes one of the major …

Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the
world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic …

Sickle cell trait (SCT; HbAS), the heterozygous state for the sickle cell allele of the beta
globin gene, is carried by as many as 100 million individuals worldwide. Nigeria has the …

Background: Sickle cell disease (SCD) is the commonest genetic disorder worldwide with a
global prevalence of 20-25 million. About 12-15 million affected persons are in Sub-Sahara …