Therapeutic targeting of the complement system: from rare diseases to pandemics

P Garred, AJ Tenner, TE Mollnes, FO Levy - Pharmacological reviews, 2021 - Elsevier
The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

A toolkit and framework for optimal laboratory evaluation of individuals with suspected primary immunodeficiency

V Knight, JR Heimall, H Chong, SL Nandiwada… - The Journal of Allergy …, 2021 - Elsevier
Knowledge related to the biology of inborn errors of immunity and associated laboratory
testing methods continues to expand at a tremendous rate. Despite this, many patients with …

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement …

M Nunes, M Vlok, A Proal, DB Kell… - Cardiovascular …, 2024 - Springer
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic
condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation …

Genetic Defects in Early-Onset Inflammatory Bowel Disease

AOB Dagci, KC Cushing - Rheumatic Disease Clinics, 2023 - rheumatic.theclinics.com
Inflammatory bowel disease (IBD) is a group of complex, multifactorial disorders
characterized by chronic inflammation of the gastrointestinal tract. The three subtypes of IBD …

The complement system: A key player in the host response to infections

A Jayaraman, S Walachowski… - European Journal of …, 2024 - Wiley Online Library
Infections are one of the most significant healthcare and economic burdens across the world
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …

Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities

Y Qin, J Ma, CG Vinuesa - Current opinion in rheumatology, 2024 - journals.lww.com
Monogenic lupus: insights into disease pathogenesis and ther... : Current Opinion in
Rheumatology Monogenic lupus: insights into disease pathogenesis and therapeutic …

Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study

H Wang, G Chen, Q Gong, J Wu, P Chen - Frontiers in Immunology, 2024 - frontiersin.org
Background Currently, evidence regarding the causal relationship between primary
immunodeficiency-related genes and varicella-zoster virus reactivation syndrome is limited …

Functional genetics in inborn errors of immunity

E Rey-Jurado, MC Poli - Future Rare Diseases, 2021 - Taylor & Francis
Inborn errors of immunity are genetic defects of the immune system, causing increased
susceptibility to infection, autoinflammation, autoimmunity and immune dysregulation. Next …

Association of ficolin1 and ficolin3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

Y Li, EQ You, WH Lin, XN Liu, DP Shen… - Journal of Clinical …, 2021 - Wiley Online Library
Background The aim of our study was to estimate the association of ficolin‐1 (FCN1) gene
(rs10120023, rs1071583) and ficolin‐3 (FCN3) gene (rs3813800, rs10794501) …

纤维胶凝蛋白与冠状动脉狭窄程度相关性及其对预后的影响.

刘首宏, 张永全, 王俏 - Tianjin Medical Journal, 2023 - search.ebscohost.com
目的探讨纤维胶凝蛋白-2 (Ficolin-2), 纤维胶凝蛋白-3 (Ficolin-3) 与冠心病患者冠状动脉狭窄
程度的相关性及其对预后的影响. 方法以137 例稳定期冠心病患者为冠心病组, 根据Gensini …