Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Neural stem cell differentiation into mature neurons: mechanisms of regulation and biotechnological applications

MS Vieira, AK Santos, R Vasconcellos… - Biotechnology …, 2018 - Elsevier
The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

A Antoniou, L Auderset, L Kaurani, E Sebastian… - Cell reports, 2023 - cell.com
Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …

miR-323a regulates ERBB4 and is involved in depression

LM Fiori, A Kos, R Lin, JF Théroux, JP Lopez… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is a complex and debilitating illness whose etiology
remains unclear. Small RNA molecules, such as micro RNAs (miRNAs) have been …

Ontogeny of the circadian system: a multiscale process throughout development

M Comas, DDP Tonelli, L Berdondini, M Astiz - Trends in Neurosciences, 2024 - cell.com
The 24 h (circadian) timing system develops in mammals during the perinatal period. It
carries out the essential task of anticipating daily recurring environmental changes to identify …

ZEB1 represses neural differentiation and cooperates with CTBP2 to dynamically regulate cell migration during neocortex development

H Wang, Z Xiao, J Zheng, J Wu, XL Hu, X Yang… - Cell reports, 2019 - cell.com
Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal
transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and …

miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes …

S Pulcrano, R De Gregorio, C De Sanctis… - Journal of …, 2023 - Soc Neuroscience
In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic
plasticity at a higher level by acting as an additional mechanism of translational regulation …

Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus

C Gasperini, K Tuntevski, S Beatini, R Pelizzoli… - EMBO …, 2023 - embopress.org
Adult neural progenitor cells (aNPCs) ensure lifelong neurogenesis in the mammalian
hippocampus. Proper regulation of aNPC fate has thus important implications for brain …

MiR-135a-5p is critical for exercise-induced adult neurogenesis

M Pons-Espinal, C Gasperini, MJ Marzi, C Braccia… - Stem Cell Reports, 2019 - cell.com
Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant
strategy for preventing age-related cognitive decline in humans. The underlying …