Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

Gene transcription profiles across tissues are largely defined by the activity of regulatory
elements, most of which correspond to regions of accessible chromatin. Regulatory element …

Genomic imprinting results in gene expression bias caused by parental chromosome of
origin and occurs in genes with important roles during human brain development. However …

Genetic studies often seek to establish a causal chain of events originating from genetic
variation through to molecular and clinical phenotypes. When multiple phenotypes share a …

Female mammals are functional mosaics of their parental X-linked gene expression due to X
chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in …

Genetic background is a key but sometimes overlooked factor that profoundly impacts
disease susceptibility and presentation in both humans and disease models. Here we show …

To interpret the function of genetic variants associated with neuropsychiatric disorders and
interindividual variation in other brain-relevant traits, expression quantitative trait loci (eQTL) …

Genomic imprinting results in gene expression biased by parental chromosome of origin
and occurs in genes with important roles during human brain development. However, the …

Imprinted genes have been linked with diseases ranging from cancer, to metabolic
syndromes, to psychiatric illness. With regard to psychiatric illness in particular, numerous …

Female mammals are functional mosaics of their parental X-linked gene expression due to X
chromosome inactivation (XCI). This process inactivates one copy of the X chromosome in …