Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …
C Wang, Y Pang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering from their lower bioavailability which highly restricts the treatment efficacy. The introduction …
A Tomlinson, AJ Bron, DR Korb… - … & visual science, 2011 - tvst.arvojournals.org
Diagnostic tests of meibomian gland dysfunction (MGD) and of MGD-related disorders are based on the demonstration of abnormal anatomy and physiology of the glands and the …
Publication of the DEWS report in 2007 established the state of the science of dry eye disease (DED). Since that time, new evidence suggests that a rethinking of traditional …
L Cwiklik - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …
Understanding the molecular composition (eg, proteins and lipids) of the tear film (TF) and the contribution of the meibomian gland to the TF is critical in gaining knowledge about TF …
LE Downie, S Bandlitz, JPG Bergmanson… - Contact Lens and …, 2021 - Elsevier
A key element of contact lens practice involves clinical evaluation of anterior eye health, including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal …
IA Butovich - Experimental eye research, 2013 - Elsevier
Human meibomian gland secretions (MGS, or meibum) are formed from a complex mixture of lipids of different classes such as wax esters, cholesteryl esters,(O-acyl)-ω-hydroxy fatty …
S McGinnigle, SA Naroo, F Eperjesi - Survey of ophthalmology, 2012 - Elsevier
Dry eye is a common yet complex condition. Intrinsic and extrinsic factors can cause dysfunction of the lids, lacrimal glands, meibomian glands, ocular surface cells, or neural …