Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …

The role of endocrine disruptors (EDs) in the human prostate gland is an overlooked issue
even though the prostate is essential for male fertility. From experimental models, it is known …

The endometrium is a complex multicellular tissue that is exquisitely sensitive to the actions
of sex steroids synthesised in the ovary (endocrine system). Recent studies have highlighted …

Testosterone (T) is the predominant endogenous androgen in the bloodstream. At the
vascular level, T presents genomic and non-genomic effects, and both effects may overlap …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Androgen signaling is a critical determinant of timely and proper development of all male
organs including the prostate. Maturation of prostate and its neoplastic transformation is …

Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly.
Besides the lack of therapies, these ailments share a neuroinflammation that is …

Head and neck squamous cell carcinoma (HNSCC), the most prevalent cancer in the head
and neck region, develops from the mucosal epithelium of the upper aerodigestive tract. Its …

Introduction. Androgen signaling comprises nongenomic and genomic pathways.
Nongenomic actions are not related to the binding of the androgen receptor (AR) and occur …

The androgen receptor (AR) plays an important role in PCa metabolism, with androgen
receptor pathway inhibition (ARPI) subjecting PCa cells to acute metabolic stress caused by …