In Vitro Metabolism of Targeted Covalent Inhibitors and Their Thiol Conjugates by Gut Microbiome from Rats, Mice, and Humans

TJ Gu, J Cai, A Auster, E Torres, D Zhang… - Drug Metabolism and …, 2024 - Elsevier
Targeted covalent inhibitor (TCI) represents a non-canonical class of small molecules that
function via “inactivating” the target protein through the formation of drug-protein adducts …

Anaerolentibacter hominis gen. nov. sp. nov., Diplocloster hominis sp. nov. and Pilosibacter fragilis gen. nov. sp. nov., isolated from human faeces

Y Yan, Q Zhao, C Xu, R Wei… - … Journal of Systematic …, 2024 - microbiologyresearch.org
Three Gram-positive, obligately anaerobic bacterial strains, namely CSJ-1T, CSJ-3T, and
CSJ-4T, were isolated from faeces of healthy persons. They were characterized through a …

Genome-based reclassification of Suonthocola fibrivorans as a later heterotypic synonym of Diplocloster agilis

YC Heng - International Journal of Systematic and …, 2025 - microbiologyresearch.org
Both the genera Suonthocola and Diplocloster are members of the family Lachnospiraceae.
Their type species, both Suonthocola fibrivorans Sanger_33T and Diplocloster agilis …