Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are
generally considered to be chemically inert, the recent emergence of methods for C–H …

Highlights•Engineered hemoproteins expand the biocatalytic repertoire.•Different
hemoprotein scaffolds offer diverse activities and selectivities.•New enzymes enable …

Recent developments of stereoselective biocatalytic and chemocatalytic methods are
discussed. The review provides a guide to the use of biocatalytic methods in the area of …

Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

Small carbocycles are structurally rigid and possess high intrinsic energy due to their ring
strain. These features lead to broad applications but also create challenges for their …