IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Our understanding of myeloid factors has been brought about we will focus on how
alteration of myeloid transcription by a number of different methods. Initially, myeloid factors …

Hox genes are well-known transcriptional regulators that play an essential role in directing
embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 …

Class I homeobox (Hox) genes encode a major group of transcription factors controlling
embryonic development and have been implicated in the continuing process of …

Hox genes were first recognized for their role in embryonic development and may also play
important lineage-specific functions in a variety of somatic tissues including the …

Hox genes have a well-characterized role in embryonic development, where they determine
identity along the anteroposterior body axis. Hox genes are expressed not only during …

Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant
cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the …

The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the
epigenetic maintenance of transcriptional memory and the pathogenesis of human …

Adipose tissue located within the abdominal cavity has been suggested to be functionally
and metabolically distinct from that of the subcutaneous compartment. These differences …

Abstract The t (7; 11)(p15; p15) translocation is a recurrent chromosomal abnormality
associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the …