Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

In vitro differentiation of human intestinal organoids (HIOs) from pluripotent stem cells is an
unparalleled system for creating complex, multicellular three-dimensional structures capable …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …

The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve leads
to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to …

In plants, the photosynthetic machinery photosystem II (PSII) consists of a core complex
associated with variable numbers of light-harvesting complexes II (LHCIIs). The …

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …