Life as a guide to its own origins
SA Harrison, H Rammu, F Liu, A Halpern… - Annual Review of …, 2023 - annualreviews.org
The origin of life entails a continuum from simple prebiotic chemistry to cells with genes and
molecular machines. Using life as a guide to this continuum, we consider how selection …
molecular machines. Using life as a guide to this continuum, we consider how selection …
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate …
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate …
Protein folding stability and binding interactions through the lens of evolution: a dynamical perspective
Highlights•Folding stability is an important factor for evolution and provides a negative
selection pressure.•Evolution re-shuffles flexibilities to fine-tune function, thereby modulating …
selection pressure.•Evolution re-shuffles flexibilities to fine-tune function, thereby modulating …
Bridging themes: short protein segments found in different architectures
The vast majority of theoretically possible polypeptide chains do not fold, let alone confer
function. Hence, protein evolution from preexisting building blocks has clear potential …
function. Hence, protein evolution from preexisting building blocks has clear potential …
A transient vesicular glue for amplification and temporal regulation of biocatalytic reaction networks
Regulation of enzyme activity and biocatalytic cascades on compartmentalized cellular
components is key to the adaptation of cellular processes such as signal transduction and …
components is key to the adaptation of cellular processes such as signal transduction and …
From Catalysis of Evolution to Evolution of Catalysis
R Edri, LD Williams… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus The mystery of the origins of life is one of the most difficult yet intriguing
challenges to which humanity has grappled. How did biopolymers emerge in the absence of …
challenges to which humanity has grappled. How did biopolymers emerge in the absence of …
Mechanistic insights into harmine-mediated inhibition of human DNA methyltransferases and prostate cancer cell growth
CC Cho, CJ Lin, HH Huang, WZ Yang… - ACS Chemical …, 2023 - ACS Publications
Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B,
are key DNA methylation enzymes and play important roles in gene expression regulation …
are key DNA methylation enzymes and play important roles in gene expression regulation …
[HTML][HTML] Searching protein space for ancient sub-domain segments
R Kolodny - Current Opinion in Structural Biology, 2021 - Elsevier
Highlights•Sub-domain segments may carry hints to the evolution of protein
domains.•Similar sub-domain segments shared among globally dissimilar domains are …
domains.•Similar sub-domain segments shared among globally dissimilar domains are …
Driving forces in the origins of life
KA Dill, L Agozzino - Open biology, 2021 - royalsocietypublishing.org
What were the physico-chemical forces that drove the origins of life? We discuss four major
prebiotic 'discoveries': persistent sampling of chemical reaction space; sequence-encodable …
prebiotic 'discoveries': persistent sampling of chemical reaction space; sequence-encodable …
Nucleotide and codon usage biases involved in the evolution of African swine fever virus: a comparative genomics analysis
F Pu, R Wang, X Yang, X Hu, J Wang… - Journal of Basic …, 2023 - Wiley Online Library
Since African swine fever virus (ASFV) replication is closely related to its host's machinery,
codon usage of viral genome can be subject to selection pressures. A better understanding …
codon usage of viral genome can be subject to selection pressures. A better understanding …