Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

Primary cultured hepatocytes are a valuable in vitro model for drug metabolism studies.
However, their widespread use is greatly hindered by the scarcity of suitable human liver …

AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-
derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in …

Gaining knowledge on the metabolism of a drug, the enzymes involved and its inhibition or
induction potential is a necessary step in pharmaceutical development of new compounds …

Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is
frequently exposed to elevated concentrations of these compounds and become the primary …

Different types of hepatic tissue, including whole or split livers from organ donors or waste
liver from therapeutic liver resections, are used to prepare human hepatocyte cultures …

Drugs are usually biotransformed into new chemical species that may have either toxic or
therapeutic effects. Drug metabolism studies are routinely performed in laboratory animals …

In mammals, CYP3A isozymes collectively comprise the largest portion of the liver and small
intestinal CYP protein. They are involved in the metabolism of an extensive range of …