The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene
regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that …

Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of
melanocytes, with epidemiological association with other autoimmune diseases. In previous …

Genome-wide association studies have identified several loci associated with pancreatic
cancer risk; however, the mechanisms by which genetic factors influence the development of …

All cells of the immune system rely on a highly integrated and dynamic gene expression
program that is controlled by both transcriptional and post-transcriptional mechanisms …

It has been found that the majority of disease-associated genetic variants identified by
genome-wide association studies are located outside of protein-coding regions, where they …

Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with
other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap …

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Celiac disease (CD) is a complex immune-related disease with a very strong genetic
component. Multiple genetic findings over the last decade have added to the already known …

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with …