Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular matrix structures?

N Kaplan, I Yilmaz, N Karaarslan… - Current …, 2019 - ingentaconnect.com
Background: The study aimed to investigate the effects of the active ingredient, nimodipine,
on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue …

Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells

N Karaarslan, I Yilmaz, DY Sirin - Experimental and …, 2021 - spandidos-publications.com
The present study aimed to investigate the effects of paracetamol, an analgesic and
antipyretic that is used in emergency departments and neurosurgery departments for …

Are radio‐contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?

N Karaarslan, I Yilmaz, H Ozbek… - Basic & Clinical …, 2019 - Wiley Online Library
In the literature, there have been no studies showing clear results on how radio‐contrast
pharmaceuticals would affect intact disc tissue cells. In this context, it was aimed to evaluate …

Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue

FS Akgun, DY Sirin, I Yilmaz… - Experimental and …, 2019 - spandidos-publications.com
The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic,
anti‑pyretic and anti‑spasmodic used in emergency departments, on nucleus pulposus and …

Investigation of the effects of methylphenidate, an amphetamine derivative, on intervertebral disc tissue cell cultures and matrix structures

YE Kaya, N Karaarslan, DY Şirin, H Özbek, N Kaplan… - 2019 - acikerisim.rumeli.edu.tr
AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD)
cell cultures and extracellular matrix structures. Changes in the expression of some …

Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue

T Caliskan, D Yasar Sirin… - Experimental and …, 2019 - spandidos-publications.com
The aim of the present study was to investigate the effects of etanercept (ETA), a tumor
necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral …

Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant?

N Kaplan, N Karaarslan, İ Yılmaz, DY Şirin, FS Akgün… - 2019 - acikerisim.rumeli.edu.tr
AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell
cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell …

Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment

SS Lin, CC Niu, LJ Yuan, TT Tsai, PL Lai… - Journal of Orthopaedic …, 2021 - Springer
Background MicroRNA (miRNA) plays a vital role in the intervertebral disc (IVD)
degeneration. The expression level of miR-573 was downregulated whereas Bax was …

Assessment of the Impact of Curcumin on Cell Cultures Derived from the Primary Intervertebral Disc Tissue in Humans

M Albayrak, İ Yılmaz, MF Yüzbaşı, H Akalan… - Maltepe Tıp …, 2023 - dergipark.org.tr
Aim: Degenerative disc disease in the lumbar spine is widely observed. Degenerative disc
diseases are among the causes of low back pain in older age. Modern drug discovery …

The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures

T Caliskan, H Akalan, I Yilmaz… - Archives of Medical …, 2021 - pmc.ncbi.nlm.nih.gov
Introduction The present study aimed to investigate the potential effects of rivaroxaban, an
oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells …